The simple answer is to make two different products, each with 1 of your variants. The quantity discounts apply at the product level, so any variant that belongs to the product falls under those rules.
The complex answer requires source code, and requires you to modify the underlying discount structure and the way quantity discounts are handled. This will involve changes to the admin section (to set the quantity discount table structure on the variant level), the ProductVariant table (to allow the variant to be mapped to a quantity discount table), the aspdnsf_GetCartSubTotalAndTax stored procedure, the ShoppingCart class, the XSLTExtensionBase class, the AppLogic class, and most likely a few others depending on how in-depth and where you need to make sure this applies.
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